125th Street is a two-way east-west street in Manhattan, considered the "Main street" of Harlem. It runs from an interchange with the Henry Hudson Parkway east through Harlem to an interchange with F.D.R. Drive , where it becomes the Manhattan leg of the Triborough Bridge.

The following subway stations are located at 125th Street:

• at Broadway
• 125th Street on the (IND Eighth Avenue Line) at St. Nicholas Avenue
• 125th Street on the (IRT Lenox Avenue Line) at Lenox Avenue
• 125th Street on the (IRT Lexington Avenue Line) at Lexington Avenue

The Metro-North Railroad Harlem-125th Street station is also at 125th Street, where it intersects Park Avenue.