Events

• January 25 - Alfonso II becomes King of Naples.
• May 31 - Natives of the island of Tenerife, known as Guanches, defeat invading Spanish forces at the First Battle of Acentejo.
• June 7 - Spain and Portugal sign the Treaty of Tordesillas which divides the New World between the two countries.
• October 22 - Ludovico Sforza become Duke of Milan.
• Start of the Italian Wars.
• The University of Aberdeen is founded by the bishop of Aberdeen.

Births

• Saito Dosan, daimyo during the Sengoku period of Japan.
• February 2 - Bona Sforza, queen of Poland and a second wife of Sigismund I of Poland
• September 12 - King Francis I of France (d. 1547)
• November 6 - Suleiman the Magnificent, ruler of the Ottoman Empire (d. 1566)

Deaths

• January 25 - Ferdinand I, King of Naples
• November 17 - Giovanni Pico della Mirandola, Italian Renaissance humanist (b. 1463)