May 26 - A Spanish army under Hernandez Gonzalo de Cordoba lands in Calabria with the purpose of ousting the French and restoring Ferrante II to the throne of Naples.
June 28 - Battle of Seminara . Cordoba and Ferrante are defeated by a French army under Bernard Stuart, Seigneur d'Aubigny .
July 6 - Battle of Fornovo - The French army under King Charles secures its retreat from Italy by defeating a combined Milanese-Venetian force under Giovanni Francesco Gonzaga , Marquis of Mantua.