Events

• April 11 - Battle of Ravenna . French forces under Gaston de Foix, Duc de Nemours defeat the Spanish under Raymond of Cardona, but Gaston is killed in the pursuit.
• November 1 - The ceiling of the Sistine Chapel, painted by Michelangelo Buonarroti, is exhibited to the public for the first time.

• Juan Ponce de León discovers the Turks and Caicos Islands.
• Selim I succeeds Beyazid II as Sultan of the Ottoman Empire.
• Moldavia is conquered by the Turks.
• Copernicus writes Commentariolus and moves the sun to the center of the solar system.
• First use of the word "masque" to denote a poetic drama.
• Florentine Republic is dismantled and the Medici family comes back into power.

Births

• April 10/April 11 - Prince James Stuart, later King James V of Scotland.
• Catherine Parr, later sixth Queen consort of King Henry VIII of England.
• Abati, Italian artist
• Gerardus Mercator, Flemish cartographer (d. 1594)

Deaths

• February 22 - Amerigo Vespucci (b. 1454)
• November 8 - Emery d'Amboise , Grand Master of the Knights of Rhodes