Events

• April - Battle of Villalors - Forces loyal to Emperor Charles V defeat the Comuneros , a league of urban bourgeois rebelling against Charles in Spain.
• June 6 - Gustav Vasa becomes King of Sweden, establishing finally its full independence from Denmark.

Births

• April 5 - Blaise de Vigenère

Deaths

• May 23 - Ashikaga Yoshitane, Ashikaga shogun
• September 14 - Pope Adrian VI
• Judah Abravanel, Jewish philosopher, physician and poet.