The A10 is a major road in England. Starting at London Bridge, it runs northward through Tottenham and Enfield. After the road's junction with the M25 motorway at Waltham Cross , the road bypasses Cheshunt, Hoddesdon, Ware and Buntingford. From Ware, the road used to pass through several Hertfordshire villages such as Wadesmill and Thundridge , but these are now bypassed by a 4-mile extension of the dual carriageway from London which opened in late 2004. From Buntingford, the road runs through Royston and around Cambridge via the M11 motorway, and then bypasses Ely and Downham Market before reaching the coast at King's Lynn in Norfolk. Its northern section runs up the valley of the River Great Ouse.

Parts of the section from London to Royston follow the route of the Roman Ermine Street.

A10 (Switzerland) is an expressway in Switzerland.