Alexis Arquette (b. 1 January 1969, Los Angeles, California) is an American actor, musician, drag and pornographic performer who is part of a family of actors including Patricia Arquette, David Arquette and Rosanna Arquette. He is openly gay. The least well known of his siblings, the majority of his film work has been limited to low-budget or independent films. These have included his critically acclaimed debut performance as transexual Georgette in Last Exit To Brooklyn . He also appeared in I Think I Do , Children of the Corn V and Killer Drag Queens on Dope , among 40 other independent pictures.

Arquette has infrequently popped in quirky supporting roles in mainstream films, including Pulp Fiction, Threesome, Bride of Chucky and a memorable appearance as a Boy George impersonator in The Wedding Singer. Arquette is well known in California for his drag persona "Eva Destruction", and he has also performed in low-budget pornographic films.

In 2004 Arquette expressed an interest in fully making a transition from male to female by the use of hormone treatments and, ultimately, sex reassignment surgery.