Alypius of Antioch was a geographer of the mid 4th century who was sent by the emperor Julian into Britain as vicarius. He ruled during a difficult period and he was probably considered suitable for the post because he came from the far east of the empire had no associations with the west. He may have had to deal with the insurrection of the usurper named 'Carausius II'

Alypius was afterwards commissioned to rebuild the Temple in Jerusalem as part of Julian's systematic attempt to reverse the Christianization of the Roman Empire by restoring pagan and, in this case, Jewish practices. Among the letters of Julian are two (29 and 30) addressed to Alypius; one inviting him to Rome, the other thanking him for a geographical treatise, which no longer exists.