Appomattox may refer to:

• Appomattox -- town in Virginia
• Appomattox County -- county in Virginia
• Appomattox Basin -- region in Virginia
• Appomattox Court House -- court house and National Historical Park in Virginia
• Appomattox Manor -- manor in City Point
• Appomattox River -- river in Virginia
• Battle of Appomattox Courthouse -- battle of American Civil War
• Battle of Appomattox Station -- battle of American Civil War