Argo 16 was the codename of an aircraft used by the Italian Secret Service and the US Government in classified operations. The aircraft crashed on November 23, 1973 at Marghera , Italy after an IED detonated onboard. Venetian Judge Carlo Mastelloni determined that the Argo 16 aircraft was used to shuttle trainees and munitions of NATO members between the military bases around Italy.

It is believed the sabotage was carried out by Mossad, in retaliation for the pro-Libyan Italian government's decision to expel, rather than try, five arabs who had tried to blow up an Israeli airliner. The Arabs had been spirited out of the country on board the Argo 16.

The are many conspiracy thories surrouding this crash. Many believe that the aircraft was used by CIA in the Cold War conflict.