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Budesonide


Budesonide

16,17-(butylidenebis(oxy))-11,21-dihydroxy-,
(11-β,16-α)-pregna-1,4-diene-3,20-dione
CAS number
51333-22-3
ATC codes
A07EA06, D07AC09, R01AD05, R03BA02
Chemical formula CH34O6
Molecular weight 430.5376
Bioavailability 6%
Metabolism Hepatic
Elimination half-life 2-3 Hours
Excretion Renal, Faecal
Pregnancy category C (USA)
Legal status  ?
Routes of administration Nasal, tracheal, rectal

Budesonide is a corticosteroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. Additionally, it is used for inflammatory bowel disease. It is marketed by AstraZeneca as a nasal inhalation with the brand name Rhinocort, as an oral inhalation with the brand name Pulmicort, and as an enema with the brand name Entocort. It is also sold in combined with formoterol (Oxis) in a single inhaler, with the brand name Symbicort.

Budesonide has a high first pass metabolism. It has efficacy in the terminal ileum and the right colon. It has a lower incidence of systemic manifestations than similar medications.

Last updated: 10-11-2005 01:39:26
Last updated: 01-04-2007 01:18:57
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