Carl Ludwig Blume (29 June 1789 - 3 February 1862) was a German-Dutch botanist.

He was born at Braunschweig in Germany, but spent most of his professional life working in the Netherlands, where he was Director of the Rijksherbarium (state herbarium) at Leiden. His name is sometimes given in the Dutch language form Karel Lodewijk Blume, but the original Germanic spelling is the one most widely used in botanical texts.

He carried out extensive studies of the flora of southern Asia, particularly in Java, then a colony of the Netherlands.

The botanical journal Blumea is named after him.