Cleve B. Moler is a mathematician and computer programmer specializing in numerical analysis. In the mid to late 1970s, he was one of the authors of LINPACK and EISPACK, Fortran libraries for numerical computing. He invented MATLAB, a numerical computing package, to give his students at the University of New Mexico easy access to these libraries without writing Fortran. In 1984, he co-founded The MathWorks with Jack Little to commercialize this program.

He received his bachelor's degree from Caltech in 1961, and a Ph.D. from Stanford University.

He was a professor of math and computer science for almost 20 years at the University of Michigan, Stanford University, and the University of New Mexico. Before joining The MathWorks full time in 1989, he also worked for Intel Hypercube and Ardent. He is also co-author of four textbooks on numerical methods and is a member of the Association for Computing Machinery. He was vice-president of the Society for Industrial and Applied Mathematics and currently sits on its Board of Trustees.

He was elected to the National Academy of Engineering on February 14, 1997. He received an honorary degree from Linkoping University, Sweden. He received an honorary degree of Doctor of Mathematics from the University of Waterloo on June 16, 2001. On April 30, 2004, he was appointed Honorary Doctor (doctor technices, honoris causa) at the Technical University of Denmark.