The Delta Cultural Center is a cultural center and museum located in Helena, Arkansas dedicated to preserving and interpreting the culture of the Mississippi River delta region.

The center consists of three buildings in downtown Helena, Arkansas.

• A Visitors Center which houses an interactive exhibition of Delta music including the King Biscuit Blues Festival and the broadcast facilities for King Biscuit Time which is the longest running blues radio program in the nation.

• The Train Depot which houses an exhibit of the American Civil War in Helena including the Battle of Helena, Union occupation of the area, slave experiences, and women in Civil War Helena. The Train Depot also has exhibits on the history of the Mississippi River including the Great Mississippi Flood of 1927 and exhibits on Delta agriculture and Native American history.

• The Moore-Hornor House is a Greek Revival/Italianate-style home. The back yard of the home saw fierce hand-to-hand fighting during the Battle of Helena in the Civil War and will house Living History presentations and archaeology exhibits when restoration is completed.