Domenico Zipoli (October 17, 1688 – January 2, 1726) was an Italian Baroque composer. He was the most famous Italian composer to travel to the New World during the Colonial era.

Zipoli was born in Prato , Italy. From 1707 he studied with church musicians in Florence with the patronage of Cosimo III, Grand Duke of Tuscany. For a very brief time, he studied with Alessandro Scarlatti. From 1709 to 1716 he studied and worked in Rome; his teacher there was Bernardo Pasquini.

On July 1, 1716 Zipoli joined the Jesuits and he moved to Seville and the following year he moved to Paraguay. There he completed his studies in theology and philosophy, in preparation to be ordained a priest. By the time a bishop got there to for the ordaining ceremony, Zipoli had died of tuberculosis.

Today Zipoli is best known for his harpsichord music. He wrote a mass while in Paraguay, a copy of which survived in the archives of Sucre, Bolivia. He also wrote oratorios and motets, but very few of those survive.

Zipoli died in Santa Catalina near Córdoba, Argentina.