Edward Ball Cole (23 September 1879 - 18 June 1918) was an officer in the United States Marine Corps during World War I.

Cole was born in Boston, Massachusetts. One of the country's leading experts on machineguns, he received a direct commission in the Marine Corps in World War I. Major Cole received a Distinguished Service Cross for heroism during the Battle of Belleau Wood (10 June 1918) in which he was mortally wounded. He died 18 June 1918 and is buried at Mouroux Cemetery , France.

USS Cole (DD-155) was named for him. Another USS Cole was named for Darrell S. Cole.