The Enciclopedia universal ilustrada europeo-americana (also called Enciclopedia Espasa, or Enciclopedia Espasa-Calpe, after its publisher) is a Spanish encyclopaedia comprising 72 volumes published from 1908 to 1930 plus a ten-volume appendix published 1930-1933. Between 1935 and 1999, 31 supplemental volumes were published plus an index, another A-Z appendix, and an atlas, for a total of 116 volumes.

The aim of the publishers was to produce an enclyclopedia reference book in Spanish that covered scientific and technological knowledge as well as history, biographies, geography, arts, and the literature of Spain and Latin America.

According to calculations made by its publishers, the encyclopaedia has more than 165,000 pages and 200 million words.

Only minor revisions have been made to the original volumes, such as the rewrite of a part of the 1910 "Bicicleta" article which had enumerated a "pistol or revolver" as one of the things to be taken on a bicycle tour.