Forsyth Street runs from Houston Street south to East Broadway in Manhattan.

Its southern portion, separated from the rest by a one-block interruption north of Canal, runs through Chinatown parallel to the Manhattan Bridge. Along this southern stretch, one can board a number of so-called “Chinatown buses” (operated by different companies) to cities across North America, including Boston, Philadelphia, Detroit and Washington, D.C..

From south to north, Forsyth starts from East Broadway , intersects Berry Street and ends at Canal Street, then continues from Hester Street, intersects Grand Street, Broome Street , Delancey Street, Rivington Street and Stanton Street , and ends at Houston Street.