Francesco Onofrio Manfredini (June 22, 1684 – October 6, 1762) was an Italian baroque composer, violinist, and church musician.

He was born at Pistoia and studied violin with Giuseppe Torelli. He became a professional violinist, holding important posts in Bologna.

He became musical director at St. Philip's Cathedral in his home town of Pistoia, where he remained until his death.

Much of his music is presumed to have been destroyed after his death; only 43 published works and a handful of manuscripts are known. He is known to have composed oratorios, but only his instrumental works are currently performed. Among these, his concerto grossos and sinfonias show a wealth of creativity and invention.