George Woodward Wickersham (September 19, 1858–January 26, 1936) was an American lawyer and Presidential Cabinet Secretary.

Born in Pittsburgh, Pennsylvania, he graduated from the University of Pennsylvania. In 1883 Wickersham entered the old established law firm of Strong and Cadwalader, and became a partner four years later.

He held the office of Attorney General of the United States from 1909 to 1913, in the administration of President William Howard Taft.

Wickersham was named by Woodrow Wilson to serve on the War Trade Board to Cuba soon after the United States entered World War I. In 1929 Herbert Hoover named him to the National Commission on Law Observance and Enforcement .

Wickersham died in New York City in 1936.