Six ships of the British Royal Navy, and four tenders of the RNVR , have been named HMS Isis, after the Egyptian goddess Isis.

• The first Isis was a 50-gun fourth-rate probably launched in 1744 as Colchester .
• The second Isis was the French ship Diamant captured in 1747 and converted to a 50-gun fourth-rate, continuing in use until 1766.
• The third Isis was a 50-gun fourth-rate launched in 1774, and broken up in 1810.
• The fourth Isis was a 50-gun fourth-rate launched in 1819, hulked in 1861 and sold 1867.
• The fifth Isis was an Eclipse-class protected cruiser in use from 1896 to 1920.
• The sixth Isis (D87) was an I-class destroyer launched in 1936.