The House of Joseph (sometimes reffered to as the Tribe of Joseph) were the Old Testament tribes of Ephraim and Manasseh. Both of these tribes were descendents of Joseph's two sons, Ephraim and Manasseh, who are both first mentioned in Genesis 41:50-52. In Genesis 48 Ephraim and Manasseh are taken to see a dying Jacob, who blesses Ephraim (the younger son) with his right hand and Manasseh with his left hand (see Genesis 48:14,19)

The house of Joseph is mentioned in the Bible several times, notably in Numbers 13:11; Deuteronomy 27:12; Judges 1:22,35; and Ezekiel 47:13. There is also an allusion to the house of Joseph in Psalm 80:1.

Both the Samaritan sect and the Church of Jesus Christ of Latter-day Saints claim Joseph as one of their ancient tribal patriarchs. In Latter-day Saint interfaith relations with Jews, the LDS Church sometimes calls its people "Joseph", whilst calling the Jews "Judah", emphasizing beliefs of close kinship and mutual sacred covenant. Latter Day Saints do not believe themselves to be exclusively descended from these specific tribes, but in their use of names they associate themselves most closely with specific dominant tribes. No denomination of Judaism affirms the Samaritan or LDS beliefs, nor similar beliefs adhered to by anyone else.