Joe E. Brown may refer to several people:

• Joseph Evans Brown (July 28, 1892 - July 6, 1973), American screen actor, portrayer of Cap'n Andy Hawks in the motion picture Show Boat
• Joseph Emerson Brown (April 15, 1821 - November 30, 1894) governor of Georgia from 1853 to 1865, and U. S. senator from 1880 to 1890.