The Kuskokwim Mountains is a range of mountains in southwestern Alaska west of the Alaska Range and southeast of the Yukon River, at about . The mountain range is about 400 km (250 miles) long from northeast to southwest and about 80 km (50 miles) wide.

The range takes its name from the Kuskokwim River, which flows through the mountains.

Reported and defined in 1898 by Spurr of the USGS. Spurr applied the name "Tanana Hills" to the low mountains at the northeast end of what are now the Kuskokwim Mountains.