The A46 around Leicester leaves the M1 at J21a. There is only access onto the M1 Southbound, and off the M1 Northbound. There are several junctions around Leicester:

Kirby Muxloe and Glenfield South (with access to the A47 and LFE.

A50 between Glenfield and Groby, with access to the M1 Northbound. This is also a main route into Leicester.

Anstey and Glenfield North. This is the exit for Beaumont Leys and the National Space Centre.

A6 near Birstall. This is the exit for Leicester North, Loughborough and the Soar Valley.

The Leicester Western Bypass ends at the Hobby Horse Island, near Syston where it joins the old A46 going North, and the A607 (formerly A46) towards Leicester and Thurmaston.