The M53 motorway is a major road in England, running from Wallasey on the opposite bank of the River Mersey to Liverpool, along the Wirral peninsula past Birkenhead, Tranmere and Ellesmere Port to just east of Chester, upon which motorway regulations end and it seamlessly becomes the A55 road, which continues throughout North Wales, ending in Holyhead.

See also: List of motorways in the United Kingdom