Makonnen Endelkachew (1890 - 1963) was an Ethiopian official under Emperor Haile Selassie.

Makonnen accompanied Haile Selassie during his tour of Europe from April 16 to September 4, 1924. He served as Ethiopia's first Prime Minister, beginning when Haile Selassie created the position in 1942 shortly after retaking control of Ethiopia after the Italian invasion, and ending when he retired on November 1, 1957.

Makonnen Endelkachew should not be confused with his son, Endelkachew Makonnen who was also an Ethiopian political figure.