Margaret of Dampierre (1350–1405) was Countess of Flanders and twice Duchess of Burgundy. Through her mother, Margaret was also the heiress of the Duchies of Brabant and Limburg.

She was the daughter and heir of Louis de Mâle , Count of Flanders, Count of Nevers, and Count of Rethel (1346–1383). By marriage to Margaret of Brabant, daughter of John III, Duke of Brabant, Louis was also Count of Burgundy and Count of Artois (1382–1383).

In 1357, at the age of seven, she married Philip of Rouvres, grandson and heir of Eudes IV, Duke of Burgundy. Philip was eleven years old and her second cousin. He was count of Burgundy and Artois (1347–1361), Duke of Burgundy (1349–1361), Count of Auvergne and Boulogne (1360–1361).

Margaret was widowed in 1361 and in 1363 Philip the Bold became Duke of Burgundy and married Margaret in 1369. Philip had earlier been Duke of Touraine (1359–1363), and was later also count of Charolais (1390–1404). When Margaret's father died in 1383, she and Philip inherited the counties of Artois, Flanders, Nevers, and Rethel. Philip died in 1404, and Margaret died the next year.

Her eldest son, John the Fearless, succeeded her in 1405 as Duke of Burgundy, Count of Burgundy, Count of Artois, and Count of Flanders. In 1406 her younger son Anthony inherited Brabant and Limburg.