The Microsoft Natural Keyboard was introduced by Microsoft in 1995. The keyboard was a split keyboard with each half of the keyboard separated and tilted inwards towards the center of the keyboard. This key arrangement was ergonomically designed to prevent carpal tunnel syndrome and other repetitive strain injuries associated with typing for long periods of time. The keyboard also helps to ensure correct posture while sitting in at the computer.

Although it wasn't the first ergonomic keyboard, it was the first that was widely available and reasonably priced.

In 1999 Microsoft introduced the Natural Keyboard Pro as a upgraded replacement for the original Natural Keyboard.