Oto-Manguean languages are a large family of Native American languages spoken in Mexico. The family consists of the smaller groups of:

• Oto-Pamean languages
• Popolocan languages (or Chocho-Popolocan languages )
• Mixtecan languages
• Zapotecan languages
• Manguean languages (or Chiapanec-Manguean languages )
• Chinantecan languages
• The Amuzgo isolate

Some classifications also include the Tlapanec languages and Huave languages .