Rio Grande may refer to the following places:

• Rio Grande, a river to the Gulf of Mexico, in the USA and Mexico
• Rio Grande (Paraná), a river to the Paraná, in Brazil
• Rio Grande (São Francisco) , a river to the Saõ Francisco, in Brazil
• Rio Grande (Atlantic Ocean) , a river to the Atlantic Ocean, in Brazil
• Río Grande de Santiago, a river in Mexico, see Lerma
• Rio Grande, Rio Grande do Sul , a city in Brazil
• Rio Grande City, Texas, a city in the USA
• Rio Grande, New Jersey, a town in the USA
• Rio Grande, Ohio, a town in the USA
• Rio Grande, Argentina, a town in Tierra del Fuego, Argentina
• Rio Grande, Puerto Rico, a town
• Rio Grande do Norte, a Brazilian state
• Rio Grande do Sul, a Brazilian state
• Rio Grande County, Colorado, a county in the USA
• Denver and Rio Grande Western Railroad, a defunct railroad in the USA

There is also a movie called Rio Grande.