Santa Cruz, Spanish & Portuguese for "Holy Cross", is the name of several cities, regions, and other geographical features around the world:

Argentina

• Santa Cruz, Argentina
• Santa Cruz Province, Argentina

Bolivia

• Santa Cruz, Bolivia
• Santa Cruz Department
• Santa Cruz de la Sierra

Brazil

• Santa Cruz, Espirito Santo, Brazil
• Santa Cruz, Paraíba, Brazil
• Santa Cruz, Pernambuco, Brazil
• Santa Cruz, Rio Grande do Norte, Brazil
• Santa Cruz do Arari , Pará
• Santa Cruz da Baixa Verde , Pernambuco
• Santa Cruz Cabrália , Bahia
• Santa Cruz do Capibaribe , Pernambuco
• Santa Cruz da Conceição , São Paulo
• Santa Cruz do Escalvado , Minas Gerais
• Santa Cruz da Esperança , São Paulo
• Santa Cruz de Goiás , Goiás
• Santa Cruz dos Milagres , Piauí
• Santa Cruz de Minas , Minas Gerais
• Santa Cruz de Monte Castelo , Paraná
• Santa Cruz das Palmeiras , São Paulo
• Santa Cruz do Piauí , Piauí
• Santa Cruz do Rio Pardo , São Paulo
• Santa Cruz de Salinas , Minas Gerais
• Santa Cruz do Sul , Rio Grande do Sul
• Santa Cruz da Vitória , Bahia

Cape Verde

• Santa Cruz, Cape Verde

Costa Rica

• Canton of Santa Cruz , Guanacaste Province

Chile

• Santa Cruz, Chile

Cuba

• Santa Cruz del Norte
• Santa Cruz del Sur

Dominican Republic

• Santa Cruz de El Seibo

Ecuador

• Isla Santa Cruz , Galápagos Islands

Guatemala

• Santa Cruz del Quiché

India

• Santacruz, a suburb of Mumbai
• Santa Cruz, Goa , a town in the state of Goa

Mexico

• Santa Cruz de Juventino Rosas
• Santa Cruz, Sonora

Peru

• Santa Cruz de Flores , Lima Provincias region
• Santa Cruz Province, Peru

Philippines

• Santa Cruz, Laguna

Portugal

• Santa Cruz, Almodôvar, Portugal
• Santa Cruz (Armamar) , a parish in the district of Armamar
• Santa Cruz (Coimbra) , a parish in the district of Coimbra
• Santa Cruz, Portugal , a parish and a district
• Santa Cruz (Santiago do Cacém) , a parish in the district of Santiago do Cacém
• Santa Cruz (Vinhais) , a parish in the district of Vinhais
• Santa Cruz das Flores, a borough on the island of Flores in the northwestern part of the Azores
• Santa Cruz (Azores) , a parish in the district of Lagoa

Spain

• Santa Cruz del Valle de los Caídos, Madrid
• Santa Cruz de Boedo municipality Palencia
• Santa Cruz de Bezana Cantabria
• Santa Cruz del Grío municipality Zaragoza
• Santa Cruz de la Salceda , municipality Burgos
• Santa Cruz de la Serós , municipality Huesca
• Santa Cruz de Tenerife, a city in the Canary Islands
• Santa Cruz de Tenerife (province)
• Santa Cruz de La Palma Canary Islands

United States

• Santa Cruz County, Arizona
• Santa Cruz, California
• Santa Cruz County, California
• Santa Cruz Island, California
• Santa Cruz Mountains, California
• Santa Cruz, Texas

Venezuela

• Santa Cruz del Zulia , Venezuela

other

Santa Cruz is the name of a Brazilian soccer team:

• Santa Cruz Futebol Clube