Spencer Horatio Walpole (1807-1898) was a British politician, three times Home Secretary under Lord Derby. His son, Spencer Walpole, was a notable historian.

|- style="text-align: center;" | width="30%" |Preceded by:
Sir George Grey, Bt | width="40%" style="text-align: center;" |Home Secretary
1858–1859 | width="30%" |Succeeded by:
Thomas Sotheron-Estcourt

|- style="text-align: center;" | width="30%" |Preceded by:
Sir George Grey, Bt | width="40%" style="text-align: center;" |Home Secretary
1866–1867 | width="30%" |Succeeded by:
Gathorne Hardy