Spic and Span is a major U.S. brand of powdered all-purpose household cleanser. It must be mixed in water prior to use. It is strongly scented. The product name is a slangish synonym for "clean".

Spic and Span is made by Procter & Gamble, a major international manufacturer of household and personal products based in Cincinnati, Ohio. This product has sponsored many soap operas, serving perhaps most notably as the main sponsor of Search for Tomorrow for two decades.