Sylvain Sylvain (born Sylvain Mizrahi, 1949- ) is a rock and roll guitarist.

He was born in Cairo, but raised in New York City, where his family had moved due to the anti-semitic policies of Egyptian dictator Gamel Abdel Nasser.

He played guitar in the proto-punk group, the New York Dolls, until the group's final dissolution in February 1977. Sylvain and singer David Johansen were the last remaining members at the time the group broke up.

He is the cousin of fashion designer Isaac Mizrahi.