The U.S. District Court for the Middle District of North Carolina 24 counties in the center of North Carolina. It consists of five divisions with a headquarters in Greensboro, North Carolina.

The Durham division covers Chatham, Durham, Lee, Orange, and Person counties.

The Greensboro division includes: Alamance, Caswell, Guilford, Randolph, and Rockingham counties.

The Rockingham division hears cases for: Hoke, Montgomery, Moore, Richmond, and Scotland.

The Salisbury division includes: Cabarrus, Davidson, Davie, Rowan, and Stanly counties.

The Winston-Salem division covers: Forsyth, Stokes, Surry, and Yadkin counties.