The term Whetstone can refer to:

• A London district; see Whetstone, London.
• A stone used for sharpening knives and other cutting tools; see Whetstone (tool) .
• A benchmark for measuring computing power; see Whetstone (benchmark).
• A brook running through Craftsbury, Vermont, USA; see Whetstone (brook) .
• Operation Whetstone, a nuclear test program in the 1960s.